6emh A 1.76 BS01 BGE A 1 V78 A91 M146 M149 A151 L206 V27 A40 M95 M98 A100 L155 D189 K191 N194 D207 T226 D138 K140 N143 D156 T170 2.7.11.24 0004672,0004707,0005524,0006468 ic50=833nM -logKd/Ki=6.08, IC50=833nM P53779 30087925 504 NQFYSVEVGDSTFTVLKRYQNLKPIIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 6emh A 1.76 BS02 C15 A 1 G215 T216 I235 L236 G237 Q291 G164 T165 I179 L180 G181 Q235 D189 K191 N194 D207 T226 D138 K140 N143 D156 T170 2.7.11.24 0004672,0004707,0005524,0006468 P53779 30087925 506 NQFYSVEVGDSTFTVLKRYQNLKPIIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 6emh B 1.76 BS01 BGE B 1 I70 A91 M146 M149 A151 L206 I25 A40 M95 M98 A100 L155 D189 K191 N194 D207 T226 D138 K140 N143 D156 T170 2.7.11.24 0004672,0004707,0005524,0006468 ic50=833nM P53779 30087925 502 NQFYSVEVGDSTFTVLKRYQNLKPIIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 6emh B 1.76 BS02 C15 B 1 G215 T216 G237 G239 Q291 G164 T165 G181 G183 Q235 D189 K191 N194 D207 T226 D138 K140 N143 D156 T170 2.7.11.24 0004672,0004707,0005524,0006468 P53779 30087925 504 NQFYSVEVGDSTFTVLKRYQNLKPIIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 6emh C 1.76 BS01 C15 A 1 E160 R165 E110 R115 D189 K191 N194 D207 T226 D139 K141 N144 D157 T166 2.7.11.24 0004672,0004707,0005524,0006468 P53779 30087925 506 NQFYSVEVGDSTFTVLKRYQNLKPIGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDEHTIEEWKELIYKEVMN 6emh C 1.76 BS02 BGE C 1 V78 A91 M146 M149 A151 Q155 L206 V28 A41 M96 M99 A101 Q105 L156 D189 K191 N194 D207 T226 D139 K141 N144 D157 T166 2.7.11.24 0004672,0004707,0005524,0006468 ic50=833nM P53779 30087925 503 NQFYSVEVGDSTFTVLKRYQNLKPIGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDEHTIEEWKELIYKEVMN 6emh D 1.76 BS01 BGE D 1 I70 M146 M149 A151 Q155 L206 I25 M96 M99 A101 Q105 L156 D189 K191 N194 D207 T226 D139 K141 N144 D157 T165 2.7.11.24 0004672,0004707,0005524,0006468 ic50=833nM P53779 30087925 503 NQFYSVEVGDSTFTVLKRYQNLKPIGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTATRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIEHTIEEWKELIYKEVMN