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BioLiP Library
Download all results in tab-seperated text for 23 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 2vdb:A (2.52) BS01 NPS ? GO:0003677 ... P02768 18259051
    2 3nt1:A (1.73) BS01 NPS 1.14.99.1 GO:0001516 ... Q05769 20810665 MOAD: ic50=0.9uM
    3 3nt1:B (1.73) BS01 NPS 1.14.99.1 GO:0001516 ... Q05769 20810665 MOAD: ic50=0.9uM
    4 3r58:A (2.3) BS02 NPS 1.1.1.-
    1.1.1.188
    1.1.1.210
    1.1.1.239
    1.1.1.357
    1.1.1.53
    1.1.1.62
    1.1.1.64    		 GO:0001523 ... P42330 22937138 BindingDB: IC50=180nM
    5 4fjp:A (1.68) BS04 NPS 3.4.21.- GO:0005576 ... P24627 N/A
    6 4jq1:A (1.6) BS01 NPS 1.-.-.-
    1.1.1.112
    1.1.1.209
    1.1.1.357
    1.1.1.53
    1.1.1.62
    1.3.1.20    		 GO:0004032 ... P52895 N/A BindingDB: IC50=1260nM
    7 4jq1:B (1.6) BS01 NPS 1.-.-.-
    1.1.1.112
    1.1.1.209
    1.1.1.357
    1.1.1.53
    1.1.1.62
    1.3.1.20    		 GO:0004032 ... P52895 N/A BindingDB: IC50=1260nM
    8 4or0:A (2.58) BS01 NPS ? GO:0003677 ... P02769 24753230 PDBbind: -logKd/Ki=7.46, Kd=35nM
    9 4or0:A (2.58) BS02 NPS ? GO:0003677 ... P02769 24753230 PDBbind: -logKd/Ki=7.46, Kd=35nM
    10 4or0:A (2.58) BS03 NPS ? GO:0003677 ... P02769 24753230 PDBbind: -logKd/Ki=7.46, Kd=35nM
    11 4or0:B (2.58) BS01 NPS ? GO:0003677 ... P02769 24753230
    12 4or0:B (2.58) BS02 NPS ? GO:0003677 ... P02769 24753230
    13 4or0:B (2.58) BS03 NPS ? GO:0003677 ... P02769 24753230
    14 4ot2:A (2.42) BS01 NPS ? GO:0003677 ... P35747 24753230
    15 4ot2:A (2.42) BS02 NPS ? GO:0003677 ... P35747 24753230
    16 4po0:A (2.73) BS01 NPS ? GO:0003677 ... G1U9S2 24753230 PDBbind: -logKd/Ki=6.92, Kd=0.12uM
    17 4po0:A (2.73) BS02 NPS ? GO:0003677 ... G1U9S2 24753230 PDBbind: -logKd/Ki=6.92, Kd=0.12uM
    18 4po0:A (2.73) BS03 NPS ? GO:0003677 ... G1U9S2 24753230 PDBbind: -logKd/Ki=6.92, Kd=0.12uM
    19 4zbr:A (2.19) BS02 NPS ? GO:0003677 ... P35747 26652101 MOAD: Ka=7730000M^-1
    20 4zbr:A (2.19) BS03 NPS ? GO:0003677 ... P35747 26652101 MOAD: Ka=7730000M^-1
    21 5dby:A (2.35) BS02 NPS ? GO:0003677 ... P35747 26652101 MOAD: Ka=7730000M^-1
    22 8jh5:A (3.7) BS01 NPS ? GO:0005515 ... Q9C6B8 N/A
    23 8jh5:B (3.7) BS01 NPS ? GO:0005515 ... Q9C6B8 N/A
    Reference:
    • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
    • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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