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BioLiP Library
Download all results in tab-seperated text for 8 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 4zum:A (1.42) BS02 FKS 3.5.1.-
    3.5.1.48
    3.5.1.62    		 GO:0004407 ... Q48935 26200446 PDBbind: -logKd/Ki=6.57, IC50=0.27uM
    2 4zum:B (1.42) BS02 FKS 3.5.1.-
    3.5.1.48
    3.5.1.62    		 GO:0004407 ... Q48935 26200446 PDBbind: -logKd/Ki=6.57, IC50=0.27uM
    3 5efh:A (2.162) BS02 FKS 3.5.1.98 N/A F8W4B7 27454933 MOAD: Ki=0.8uM
    4 5efh:D (2.162) BS02 FKS 3.5.1.98 N/A F8W4B7 27454933 MOAD: Ki=0.8uM
    PDBbind: -logKd/Ki=6.10, Ki=800nM
    5 5td7:A (2.85) BS02 FKS 3.5.1.48
    3.5.1.62    		 GO:0005634 ... F1QCV2 28516954 PDBbind: -logKd/Ki=5.77, IC50=1.7uM
    6 6phz:A (2.0) BS03 FKS ? GO:0004407 ... A0A0J7JFD7 31436969 MOAD: ic50=350uM
    PDBbind: -logKd/Ki=3.46, IC50=350uM
    7 6phz:B (2.0) BS03 FKS ? GO:0004407 ... A0A0J7JFD7 31436969 MOAD: ic50=350uM
    PDBbind: -logKd/Ki=3.46, IC50=350uM
    8 6uil:A (2.85) BS01 FKS 3.5.1.48
    3.5.1.62    		 GO:0005634 ... F1QCV2 31746596 PDBbind: -logKd/Ki=7.10, IC50=80nM
    Reference:
    • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023)(download the PDF file).
    • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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