Structure of PDB 1eed Chain P

Receptor sequence

>1eedP (length=330) Species: 5116 (Cryphonectria parasitica) [Search protein sequence]

STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTA
SEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLT
VTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKA
SLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTST
GYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGG
YVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGI
GINIFGDVALKAAFVVFNGATTPTLGFASK

3D structure

PDB

1eed X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.23.22: endothiapepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0EO	P	I7 D30 D32 G34 S74 Y75 G76 D77 D215 G217 T218 T219	I10 D33 D35 G37 S78 Y79 G80 D81 D219 G221 T222 T223	MOAD: Ki=16.2uM PDBbind-CN: -logKd/Ki=4.79,Ki=16.2uM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1eed, PDBe:1eed, PDBj:1eed
PDBsum	1eed
PubMed	1525155
UniProt	P11838\|CARP_CRYPA Endothiapepsin (Gene Name=EAPA)

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