Structure of PDB 1c9b Chain N

Receptor sequence

>1c9bN (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]

GSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREP
RTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQN
MVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVS
GKVVLTGAKVRAEIYEAFENIYPILKGFRK

3D structure

PDB

1c9b Structural basis of preinitiation complex assembly on human pol II promoters.

Chain

Resolution

2.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	N	V169 T171 F214 S216 V220 Q256 N257 F288 I292 R294 T313	V12 T14 F57 S59 V63 Q99 N100 F131 I135 R137 T156
BS02	dna	N	Q166 N167 F197 R203 T210 L212 T222 P289 F305 S307 K309 V311	Q9 N10 F40 R46 T53 L55 T65 P132 F148 S150 K152 V154

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006352	DNA-templated transcription initiation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1c9b, PDBe:1c9b, PDBj:1c9b
PDBsum	1c9b
PubMed	10619841
UniProt	P20226\|TBP_HUMAN TATA-box-binding protein (Gene Name=TBP)

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