BioLiP

Structure of PDB 2pip Chain L

Receptor sequence

>2pipL (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]

QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPI
ARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT

3D structure

PDB

2pip A surface on the androgen receptor that allosterically regulates coactivator binding.

Chain

Resolution

1.8 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DHT	L	L704 N705 M745 F764 T877	L35 N36 M76 F95 T208	BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02	ICO	L	F673 N833 Y834	F4 N164 Y165
BS03	K10	L	K720 M734 I737 Q738 I898	K51 M65 I68 Q69 I229

External links

PDB	RCSB:2pip, PDBe:2pip, PDBj:2pip
PDBsum	2pip
PubMed	17911242
UniProt	P10275\|ANDR_HUMAN Androgen receptor (Gene Name=AR)

[Back to BioLiP]

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417