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BioLiP

Structure of PDB 6fmj Chain I

Receptor sequence
>6fmjI (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQE
3D structure
PDB6fmj Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.
ChainI
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DV5 I F76 W88 Y98 R107 I109 H110 S111 Y112 H115 W117 F15 W27 Y37 R46 I48 H49 S50 Y51 H54 W56 MOAD: Kd=0.76uM
External links
PDB RCSB:6fmj, PDBe:6fmj, PDBj:6fmj
PDBsum6fmj
PubMed29650462
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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