Structure of PDB 4z6a Chain H

Receptor sequence

>4z6aH (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]

IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCEASYPGKITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWY
LTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP

3D structure

PDB

4z6a Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.

Chain

Resolution

2.25 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.4.21.21: coagulation factor VIIa.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0Z6	H	H57 G97 T98 T99 D189 S190 C191 G193 S195 S214 W215 G216	H41 G85 T86 T87 D181 S182 C183 G185 S187 S206 W207 G208
BS02	CA	H	E70 D72 E75 E80	E58 D60 E63 E68

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4z6a, PDBe:4z6a, PDBj:4z6a
PDBsum	4z6a
PubMed	26694616
UniProt	P08709\|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

[Back to BioLiP]

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417