BioLiP

Structure of PDB 2byr Chain H

Receptor sequence

>2byrH (length=204) Species: 6500 (Aplysia californica) [Search protein sequence]

HSQANLMRLKSDLFNRYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLV
YYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLS
PQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFE
IDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVK
FRER

3D structure

PDB

2byr Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.

Chain

Resolution

2.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MLK	H	Y93 S94 K143 W147 V148 Y149 Q186 Y188 C190 Y195	Y90 S91 K140 W144 V145 Y146 Q183 Y185 C187 Y192	MOAD: Kd=2.8nM
BS02	MLK	H	M116 I118 S167	M113 I115 S164	MOAD: Kd=2.8nM

Gene Ontology

	Molecular Function
GO:0004888	transmembrane signaling receptor activity
GO:0005216	monoatomic ion channel activity
GO:0005230	extracellular ligand-gated monoatomic ion channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0034220	monoatomic ion transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

PDB	RCSB:2byr, PDBe:2byr, PDBj:2byr
PDBsum	2byr
PubMed	16193063
UniProt	Q8WSF8