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BioLiP

Structure of PDB 7yq3 Chain F

Receptor sequence
>7yq3F (length=831) Species: 9606 (Homo sapiens) [Search protein sequence]
PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKE
LGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNE
ECGDICPNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHS
ECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQ
DLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGL
IEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQ
LWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALK
TNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEA
PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLCSCPKTD
SQILKELEESSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHF
TGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENN
VVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRG
LSPGNYSVRIRATSLAGNGSWTEPTYFYVTD
3D structure
PDB7yq3 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
ChainF
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F N711 P716 R717 N672 P677 R678
BS02 peptide F D496 R498 N541 H710 F714 V715 R717 D486 R488 N531 H671 F675 V676 R678
BS03 dna F R86 R271 Q272 G273 C274 H275 S323 T325 N348 R83 R261 Q262 G263 C264 H265 S313 T315 N338
External links
PDB RCSB:7yq3, PDBe:7yq3, PDBj:7yq3
PDBsum7yq3
PubMed36310231
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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