BioLiP

Structure of PDB 2byr Chain F

Receptor sequence

>2byrF (length=209) Species: 6500 (Aplysia californica) [Search protein sequence]

LHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSSTNE
VDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPV
QVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVY
SGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVN
LVVKFRERR

3D structure

PDB

2byr Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.

Chain

Resolution

2.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MLK	F	Y93 S94 K143 W147 V148 Y149 Q186 Y188 Y195	Y94 S95 K144 W148 V149 Y150 Q187 Y189 Y196	MOAD: Kd=2.8nM
BS02	MLK	F	Y55 I118 S167	Y56 I119 S168	MOAD: Kd=2.8nM

Gene Ontology

	Molecular Function
GO:0004888	transmembrane signaling receptor activity
GO:0005216	monoatomic ion channel activity
GO:0005230	extracellular ligand-gated monoatomic ion channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0034220	monoatomic ion transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

PDB	RCSB:2byr, PDBe:2byr, PDBj:2byr
PDBsum	2byr
PubMed	16193063
UniProt	Q8WSF8