Structure of PDB 7ysh Chain E

Receptor sequence

>7yshE (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]

RMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEF
KPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDV
VERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG
SKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSI
GLSHHSAWLTVL

3D structure

PDB

7ysh Structural basis for FGF hormone signalling.

Chain

Resolution

2.74 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IDS	E	K175 R209	K28 R62
BS02	SGN	E	K177 T212	K30 T65

External links

PDB	RCSB:7ysh, PDBe:7ysh, PDBj:7ysh
PDBsum	7ysh
PubMed	37286607
UniProt	P11362\|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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