Structure of PDB 3pg9 Chain E

Receptor sequence

>3pg9E (length=338) Species: 2336 (Thermotoga maritima) [Search protein sequence]

MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVA
DKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAG
PCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYL
REAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSY
NKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTL
DISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVH
PEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN

3D structure

PDB

3pg9 Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis

Chain

Resolution

2.35 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TYR	E	S31 G33 Q34 E35 R36 V38	S31 G33 Q34 E35 R36 V38
BS02	TYR	E	M1 I41 I42 G43 L66	M1 I41 I42 G43 L66

Gene Ontology

	Molecular Function
GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740	transferase activity
GO:0016832	aldehyde-lyase activity

	Biological Process
GO:0008652	amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0009073	aromatic amino acid family biosynthetic process
GO:0009423	chorismate biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3pg9, PDBe:3pg9, PDBj:3pg9
PDBsum	3pg9
PubMed	21282100
UniProt	Q9WYH8\|AROF_THEMA Phospho-2-dehydro-3-deoxyheptonate aldolase (Gene Name=aroF)

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