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Structure of PDB 8d9j Chain D

Receptor sequence >8d9jD (length=456) Species: 9606 (Homo sapiens) [Search protein sequence] TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHN RFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPF SHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEE DICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARD CHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSL HRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAY TKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIK REDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVS FYCKTAPNRAIRILPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRN FTKPQD

3D structure PDB 8d9j SAMHD1-DNA complex Chain D Resolution 2.82 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 3.1.5.-

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 dna D K116 V117 I118 I136 D137 R145 K3 V4 I5 I23 D24 R32 BS02 dna D Y155 V156 R451 L453 Y42 V43 R332 L334 BS03 CA D D207 H233 D94 H120 BS04 FE D H167 H206 D207 D311 H54 H93 D94 D192

Gene Ontology Molecular Function GO:0003676 nucleic acid binding GO:0003697 single-stranded DNA binding GO:0003723 RNA binding GO:0004540 RNA nuclease activity GO:0005515 protein binding GO:0005525 GTP binding GO:0008270 zinc ion binding GO:0008832 dGTPase activity GO:0016787 hydrolase activity GO:0016793 triphosphoric monoester hydrolase activity GO:0032567 dGTP binding GO:0042802 identical protein binding GO:0046872 metal ion binding GO:0106375 deoxynucleoside triphosphate hydrolase activity

	Biological Process
GO:0000724	double-strand break repair via homologous recombination
GO:0006203	dGTP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006955	immune response
GO:0006974	DNA damage response
GO:0009264	deoxyribonucleotide catabolic process
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response
GO:0046061	dATP catabolic process
GO:0051289	protein homotetramerization
GO:0051607	defense response to virus
GO:0060339	negative regulation of type I interferon-mediated signaling pathway
GO:0110025	DNA strand resection involved in replication fork processing

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005886	plasma membrane
GO:0035861	site of double-strand break
GO:0097197	tetraspanin-enriched microdomain

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