BioLiP

Structure of PDB 8a5w Chain D

Receptor sequence

>8a5wD (length=365) Species: 9606 (Homo sapiens) [Search protein sequence]

QVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAKIINN
TENLVRELLAVPDNYKVIFLQGGGCGQFSAVPLNLIGLKAGRCADYVVTG
AWSAKAAEEAKKFGTINIVHPKLGSYTKIPDPSTWNLNPDASYVYYCANE
TVHGVEFDFIPDVKGAVLVCDMSSNFLSKPVDVSKFGVIFAGAQKNVGSA
GVTVVIVRDDLLGFALRECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVL
EWIKNNGGAAAMEKLSSIKSQTIYEIIDNSQGFYVCPVEPQNRSKMNIPF
RIGNAKGDDALEKRFLDKALELNMLSLKGHRSVGGIRASLYNAVTIEDVQ
KLAAFMKKFLEMHQL

3D structure

PDB

8a5w L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase.

Chain

Resolution

2.78 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.6.1.52: phosphoserine transaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	E1U	D	G78 G79 C80 W107 T156 S178 Q199 K200 H335 R336 R342	G73 G74 C75 W102 T151 S173 Q194 K195 H330 R331 R337
BS02	SEP	D	H44 R45	H39 R40

Gene Ontology

	Molecular Function
GO:0004648	O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0005515	protein binding
GO:0008483	transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0042802	identical protein binding

	Biological Process
GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0008615	pyridoxine biosynthetic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:8a5w, PDBe:8a5w, PDBj:8a5w
PDBsum	8a5w
PubMed	36851825
UniProt	Q9Y617\|SERC_HUMAN Phosphoserine aminotransferase (Gene Name=PSAT1)