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Structure of PDB 7lyc Chain D

Receptor sequence >7lycD (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] RKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEAS RLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTS

3D structure PDB 7lyc Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Chain D Resolution 2.94 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number ?

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 dna D R29 K30 S32 Y42 I54 S56 R86 S87 T88 R1 K2 S4 Y14 I26 S28 R58 S59 T60 BS02 dna D R31 R33 I39 Y40 R3 R5 I11 Y12

Gene Ontology Molecular Function GO:0001530 lipopolysaccharide binding GO:0003677 DNA binding GO:0005515 protein binding GO:0030527 structural constituent of chromatin

	Biological Process
GO:0002227	innate immune response in mucosa
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0019731	antibacterial humoral response
GO:0031640	killing of cells of another organism
GO:0042742	defense response to bacterium
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0061644	protein localization to CENP-A containing chromatin
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide

	Cellular Component
GO:0000786	nucleosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0043505	CENP-A containing nucleosome

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