Structure of PDB 5mqv Chain D

Receptor sequence

>5mqvD (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]

RYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYK
MMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLL
LADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYR
DARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFN
LGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRS
LRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK

3D structure

PDB

5mqv Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK.

Chain

Resolution

2.154 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D128 K130
Catalytic site (residue number reindexed from 1)	D121 K123
Enzyme Commision number	2.7.11.1: non-specific serine/threonine protein kinase. 2.7.11.26: [tau protein] kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	D5Q	D	I15 I23 A36 M80 M82 L85 P87 L135 L138 I148	I8 I16 A29 M73 M75 L78 P80 L128 L131 I141	MOAD: ic50=8nM

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:5mqv, PDBe:5mqv, PDBj:5mqv
PDBsum	5mqv
PubMed	28338621
UniProt	P48730\|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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