BioLiP

Structure of PDB 4zro Chain D

Receptor sequence

>4zroD (length=299) Species: 33734 (Feline infectious peritonitis virus (strain 79-1146)) [Search protein sequence]

SGLRKMAQPSGVVEPCIVRVAYGNNVLNGLWLGDEVICPRHVIASDTSRV
INYENELSSVRLHNFSIAKNNAFLGVVSAKYKGVNLVLKVNQVNPNTPEH
KFKSVRPGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYV
LENGTLYFVYMHHLELGNGSHVGSNLEGEMYGGYEDQPSMQLEGTNVMSS
DNVVAFLYAALINGERWFVTNTSMTLESYNAWAKTNSFTEIVSTDAFNML
AAKTGYSVEKLLECIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGV

3D structure

PDB

4zro X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.

Chain

Resolution

2.0566 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H41 G142 C144
Catalytic site (residue number reindexed from 1)	H41 G142 C144
Enzyme Commision number	2.1.1.57: methyltransferase cap1. 2.7.7.48: RNA-directed RNA polymerase. 2.7.7.50: mRNA guanylyltransferase. 3.1.13.- 3.4.19.12: ubiquitinyl hydrolase 1. 3.4.22.- 3.6.4.12: DNA helicase. 3.6.4.13: RNA helicase. 4.6.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	F139 G142 C144 H162 H163 L164 E165 P188 S189 Q191	F139 G142 C144 H162 H163 L164 E165 P188 S189 Q191

Gene Ontology

	Molecular Function
GO:0008233	peptidase activity

	Biological Process
GO:0019082	viral protein processing

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:4zro, PDBe:4zro, PDBj:4zro
PDBsum	4zro
PubMed	26592814
UniProt	Q98VG9\|R1AB_FIPV Replicase polyprotein 1ab (Gene Name=rep)