Structure of PDB 8g0h Chain C

Receptor sequence

>8g0hC (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]

ESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWY
HFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEASKKEKDKDSKL
EKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVA
DGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
TPKEFREISYLKKLKVKKQDRIFPPET

3D structure

PDB

8g0h Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks

Chain

Resolution

3.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	K15 S16 A19 S20 R34 F44 V48 S274 G275	K13 S14 A17 S18 R32 F42 V46 S140 G141
BS02	ZN	C	C295 C311 C321	C161 C177 C187
BS03	ZN	C	C21 H53 C56	C19 H51 C54

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0008270	zinc ion binding

View graph for
Molecular Function

External links

PDB	RCSB:8g0h, PDBe:8g0h, PDBj:8g0h
PDBsum	8g0h
PubMed	38372302
UniProt	P09874\|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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