BioLiP

Structure of PDB 7v0w Chain C

Receptor sequence

>7v0wC (length=340) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFSHFLVLSAT
KMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIIL
ALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETWRLS
FSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELD
AFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLD
HYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

7v0w Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pA

Chain

Resolution

2.66 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T174 K175 T178
BS02	dna	C	R222 K315	R74 K155
BS03	dna	C	R158 L159 K160 R161 H203 K395	R10 L11 K12 R13 H55 K229
BS04	dna	C	R161 S165 A168 N196 Y200 K372	R13 S17 A20 N48 Y52 K206
BS05	ZN	C	H378 C384 C385 C392	H212 C218 C219 C226
BS06	MN	C	Q211 N213	Q63 N65
BS07	A	C	N213 P292 D307 V348 K350 S366 S368	N65 P132 D147 V188 K190 S200 S202
BS08	GTP	C	G198 S199 Q211 N213 K350 R364 K402 C419 S420 Y421	G50 S51 Q63 N65 K190 R198 K236 C253 S254 Y255

External links

PDB	RCSB:7v0w, PDBe:7v0w, PDBj:7v0w
PDBsum	7v0w
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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