BioLiP

Structure of PDB 7kpe Chain C

Receptor sequence

>7kpeC (length=296) Species: 192222 (Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819) [Search protein sequence]

KNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESA
TLTHEEHRTCIEIAVETCKGTKVKVLAGAGSNATHQAVGLAKFAKEHGAD
GILSVAPYYNKPTQQGLYEHYKAIAQSVDIPVLLYNVPGRTGCEISTDTI
IKLFRDCENIYGVKEASGNIDKCVDLLAHEPRMMLISGEDAINYPILSNG
GKGVISVTSNLLPDMISALTHFALDENYKEAKKINDELYNINKILFCESN
PIPIKTAMYLAGLIESLEFRLPLCSPSKENFAKIEEVMKKYKIKGF

3D structure

PDB

7kpe THE ALLOSTERIC SITE RESIDUE, E88 INTERACTS WITH THE INHIBITORS TO TRANSMIT THE ALLOSTERIC INHIBITION SIGNALS IN Cj.DHDPS BY FORMING A HYDROGEN BOND.

Chain

Resolution

2.06 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3VN	C	S51 A52 H59 N84 Y110	S49 A50 H57 N82 Y108
BS02	MG	C	G80 L105	G78 L103

Gene Ontology

	Molecular Function
GO:0008840	4-hydroxy-tetrahydrodipicolinate synthase activity
GO:0016829	lyase activity

	Biological Process
GO:0009085	lysine biosynthetic process
GO:0009089	lysine biosynthetic process via diaminopimelate
GO:0019877	diaminopimelate biosynthetic process
GO:0044281	small molecule metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:7kpe, PDBe:7kpe, PDBj:7kpe
PDBsum	7kpe
PubMed
UniProt	Q9PPB4\|DAPA_CAMJE 4-hydroxy-tetrahydrodipicolinate synthase (Gene Name=dapA)