Structure of PDB 7f3o Chain C

Receptor sequence

>7f3oC (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]

GSNKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKL
KNKWWYDKGECG

3D structure

PDB

7f3o Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.

Chain

Resolution

1.44 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLU	C	Y471 L500 T501 R506 G674 S675 T676 E726	Y61 L90 T91 R96 G141 S142 T143 E193
BS02	ZN	C	E452 H456	E42 H46
BS03	0YK	C	I502 P515 F516 S750 G752 N775	I92 P105 F106 S217 G219 N242

Gene Ontology

	Molecular Function
GO:0015276	ligand-gated monoatomic ion channel activity

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7f3o, PDBe:7f3o, PDBj:7f3o
PDBsum	7f3o
PubMed	34267258
UniProt	P42262\|GRIA2_HUMAN Glutamate receptor 2 (Gene Name=GRIA2)

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