BioLiP

Structure of PDB 7doo Chain C

Receptor sequence

>7dooC (length=260) Species: 395019 (Burkholderia multivorans ATCC 17616) [Search protein sequence]

APASFAALERAAGGRLGVCAIDTATGRRALHRADERFPFCSTFKAMLGAA
VLAQSVAHPGLLQQRVTYGRSDLVNYSPVTERHVDTGMTVAELCAATIQY
SDNTAANELMKRIGGPAAVTAYARSIGDDTFRLDRWETELNTALPGDLRD
TTTPAAMAANLRVLVLGDALPPAQRAQLIEWLRGNKVGDKRIRAGVPTGW
RVGDKTGTGDYGTTNDVGVLWPPSRAPIVLAVYYTQTRADAKAKDDVIAA
ATRIASATLA

3D structure

PDB

7doo Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.

Chain

Resolution

1.6 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S70 K73 S130 E166 K234 T237
Catalytic site (residue number reindexed from 1)	S41 K44 S101 E137 K205 T208
Enzyme Commision number	3.5.2.6: beta-lactamase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NXL	C	S70 S130 N132 N170 T235 G236 T237	S41 S101 N103 N141 T206 G207 T208

Gene Ontology

	Molecular Function
GO:0008800	beta-lactamase activity
GO:0016787	hydrolase activity

	Biological Process
GO:0017001	antibiotic catabolic process
GO:0030655	beta-lactam antibiotic catabolic process
GO:0046677	response to antibiotic

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Molecular Function

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Biological Process

PDB	RCSB:7doo, PDBe:7doo, PDBj:7doo
PDBsum	7doo
PubMed	28264560
UniProt	A0A0H3KN52