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Structure of PDB 6xln Chain C

Receptor sequence >6xlnC (length=1339) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence] YSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAA FRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRL VIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRS PGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRR KLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLRGETAS FDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKDYI DESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLR VDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGR MKFNRSLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRR IRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAV KEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHP THYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDE IHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDY MDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGT GMERAVAVDSGVTAVAKRGGVVQYVDASRIVIKVNEDEMYPGEAGIDIYN LTKYTRSNQNTCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRV AFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITA DIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLL RAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQ LKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGL TDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIVKV YLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLG VPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQRAYDLG ADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLG DLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYS LVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRT KMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELED

3D structure PDB 6xln Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Chain C Resolution 2.8 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 dna C R180 W183 D199 R200 D393 R394 R465 V469 R473 G537 R542 R178 W181 D197 R198 D391 R392 R463 V467 R471 G535 R540 BS02 dna C N139 G1261 R1269 M1273 N137 G1259 R1267 M1271 BS03 rna C Q510 R540 Q688 K1065 K1073 H1237 Q508 R538 Q686 K1063 K1071 H1235 BS04 1N7 C Q725 E962 I966 Q723 E960 I964 BS05 1N7 C Q46 Y47 S398 A399 V400 E458 E461 E583 Y584 Q44 Y45 S396 A397 V398 E456 E459 E581 Y582

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003899 DNA-directed 5'-3' RNA polymerase activity GO:0005515 protein binding GO:0016779 nucleotidyltransferase activity GO:0032549 ribonucleoside binding GO:0034062 5'-3' RNA polymerase activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006352	DNA-templated transcription initiation
GO:0006879	intracellular iron ion homeostasis
GO:0009408	response to heat
GO:0031564	transcription antitermination
GO:0032784	regulation of DNA-templated transcription elongation
GO:0036460	cellular response to cell envelope stress
GO:0042128	nitrate assimilation
GO:0044780	bacterial-type flagellum assembly
GO:0046677	response to antibiotic
GO:0048870	cell motility
GO:0071973	bacterial-type flagellum-dependent cell motility
GO:0090605	submerged biofilm formation
GO:2000142	regulation of DNA-templated transcription initiation

	Cellular Component
GO:0000345	cytosolic DNA-directed RNA polymerase complex
GO:0000428	DNA-directed RNA polymerase complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008023	transcription elongation factor complex
GO:0016020	membrane

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