BioLiP

Structure of PDB 6qx2 Chain C

Receptor sequence

>6qx2C (length=482) Species: 1280 (Staphylococcus aureus) [Search protein sequence]

INERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGM
TPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQG
NFGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPS
VLPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAE
LMEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQR
IVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDV
RKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEH
QKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAM
ESLQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETI
LADEEVLLQLVRDELTEIRDRFGDDRRTEIQL

3D structure

PDB

6qx2 Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	I175 A176 G178 M179 R238 S240 S330	I167 A168 G170 M171 R230 S232 S322
BS02	dna	C	R33 K43 H46 H79 H81 G82 R92 S173 I175 R272	R25 K35 H38 H71 H73 G74 R84 S165 I167 R264
BS03	JK8	C	M27 M179 I336 R342 L345	M19 M171 I328 R334 L337

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

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Molecular Function

View graph for
Biological Process

PDB	RCSB:6qx2, PDBe:6qx2, PDBj:6qx2
PDBsum	6qx2
PubMed	30962087
UniProt	Q99XG5\|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)