BioLiP

Structure of PDB 6qtk Chain C

Receptor sequence

>6qtkC (length=482) Species: 1280 (Staphylococcus aureus) [Search protein sequence]

INERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGM
TPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQG
NFGSMDGDGAAAMRFTEARMTKITLELLRDINKDTIDFIDNYDGNEREPS
VLPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAE
LMEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQR
IVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDV
RKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEH
QKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAM
ESLQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETI
LADEEVLLQLVRDELTEIRDRFGDDRRTEIQL

3D structure

PDB

6qtk Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

Chain

Resolution

2.31 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	F123 I175 V177 G178 M179 R238 S330	F115 I167 V169 G170 M171 R230 S322
BS02	dna	C	R33 K43 H46 H79 H81 G82 S85 R92 R272	R25 K35 H38 H71 H73 G74 S77 R84 R264
BS03	JHN	C	A68 M121	A60 M113

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

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Molecular Function

View graph for
Biological Process

PDB	RCSB:6qtk, PDBe:6qtk, PDBj:6qtk
PDBsum	6qtk
PubMed	30757898
UniProt	Q99XG5\|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)