Structure of PDB 6pht Chain C

Receptor sequence

>6phtC (length=343) Species: 1658765 (Marinobacter subterrani) [Search protein sequence]

SMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQALGEIL
EPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGRGMRA
RLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEGERAA
FALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVDFHHG
NGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNLNIVF
PPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFKLTSG
DYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGK

3D structure

PDB

6pht Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	OKP	C	D117 H158 H159 G167 Y168 D195 H197 F225 D284 G321 Y323	D118 H159 H160 G168 Y169 D196 H198 F226 D285 G322 Y324	MOAD: ic50=390uM
BS02	MG	C	D104 D106	D105 D107
BS03	ZN	C	D195 H197 D284	D196 H198 D285

Gene Ontology

	Molecular Function
GO:0004407	histone deacetylase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006338	chromatin remodeling

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6pht, PDBe:6pht, PDBj:6pht
PDBsum	6pht
PubMed	31436969
UniProt	A0A0J7JFD7

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