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Structure of PDB 6g07 Chain C

Receptor sequence >6g07C (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLSKTHRQSIL AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTE

3D structure PDB 6g07 Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model. Chain C Resolution 1.66 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number ?

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 peptide C I492 Q495 I229 Q232 BS02 peptide C K336 Q346 Q349 I350 P500 L501 E504 K73 Q83 Q86 I87 P237 L238 E241 BS03 EEZ C Q286 L287 C320 R364 M365 R367 A368 F377 F378 F388 I400 Q23 L24 C57 R101 M102 R104 A105 F114 F115 F125 I137 MOAD: Kd=35.5nM BindingDB: IC50=255nM,Kd=36nM

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0004879 nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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