BioLiP

Structure of PDB 5txo Chain C

Receptor sequence

>5txoC (length=556) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]

MVPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKIS
KIGPENPYNTPVFVIKKKDSTKWRKLIDLRELNKRTQDFWEVQLGIPHPA
GLKKKKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNV
LPMGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQH
RTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPE
KDSWTVNDICKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEE
AELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKN
LKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETW
ETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANR
ETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTN
SQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQV
DKLVSA

3D structure

PDB

5txo Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.

Chain

Resolution

2.546 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	W24 T27 F61 L74 N81 E89 Q91 I94 G152 W153 K154 P157 S280 R284 G285 R448 Q500	W26 T29 F63 L76 N83 E91 Q93 I96 G154 W155 K156 P159 S282 R286 G287 R450 Q502
BS02	dna	C	Y183 M184 D186 M230 G231 N255 C258 G262 W266 G359 R448 K451 T473 Q475 Y501	Y185 M186 D188 M232 G233 N257 C260 G264 W268 G361 R450 K453 T475 Q477 Y503
BS03	DTP	C	K65 R72 D110 V111 Y115 M151 D185	K67 R74 D112 V113 Y117 M153 D187
BS04	MG	C	D110 V111 D185	D112 V113 D187

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003964	RNA-directed DNA polymerase activity
GO:0004523	RNA-DNA hybrid ribonuclease activity

	Biological Process
GO:0006278	RNA-templated DNA biosynthetic process

View graph for
Molecular Function

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Biological Process

PDB	RCSB:5txo, PDBe:5txo, PDBj:5txo
PDBsum	5txo
PubMed	28396546
UniProt	P03366\|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)