Structure of PDB 5pb2 Chain C

Receptor sequence

>5pb2C (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]

IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW
YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP

3D structure

PDB

5pb2 Crystal Structure of a Factor VIIa complex

Chain

Resolution

1.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.21: coagulation factor VIIa.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	C	E270 D272 E275 E280	E58 D60 E63 E68
BS02	9RP	C	H253 S399 C400 K401 S404 S423 W424	H41 S183 C184 K185 S188 S207 W208

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5pb2, PDBe:5pb2, PDBj:5pb2
PDBsum	5pb2
PubMed
UniProt	P08709\|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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