BioLiP

Structure of PDB 5jjm Chain C

Receptor sequence

>5jjmC (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]

ECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVK
WAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPD
LVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIP
VDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQ
PIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH

3D structure

PDB

5jjm Structure of the homodimeric androgen receptor ligand-binding domain.

Chain

Resolution

2.15 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	E668 D839 P849 C852	E1 D172 P182 C185
BS02	peptide	C	K720 M734 M894	K53 M67 M227
BS03	DHT	C	L701 L704 N705 L707 Q711 M745 M749 F764 T877	L34 L37 N38 L40 Q44 M78 M82 F97 T210	BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM

External links

PDB	RCSB:5jjm, PDBe:5jjm, PDBj:5jjm
PDBsum	5jjm
PubMed	28165461
UniProt	P10275\|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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