Structure of PDB 4ps1 Chain C

Receptor sequence

>4ps1C (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]

DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTT
TFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI
IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVR
YIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILT
ILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPS

3D structure

PDB

4ps1 Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.

Chain

Resolution

1.731 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	R258 D259 H317 G318 C360 Q361
Catalytic site (residue number reindexed from 1)	R36 D37 H95 G96 C138 Q139
Enzyme Commision number	3.4.22.61: caspase-8.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	R260 H317 Q358 C360 S411 Y412 R413 W420	R38 H95 Q136 C138 S170 Y171 R172 W179

Gene Ontology

	Molecular Function
GO:0004197	cysteine-type endopeptidase activity
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4ps1, PDBe:4ps1, PDBj:4ps1
PDBsum	4ps1
PubMed	25079698
UniProt	Q14790\|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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