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BioLiP

Structure of PDB 2vof Chain C

Receptor sequence
>2vofC (length=150) Species: 10090 (Mus musculus) [Search protein sequence]
LGSMAESELMHIHSLAEHYLQYVLQVPAFEPSQACRVLQRVAFSVQKEVE
KNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVL
LKKLKQEQIALDVSAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFE
3D structure
PDB2vof Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1.
ChainC
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C E47 N51 E48 N52
BS02 peptide C E47 L52 Y55 D58 F59 I70 V74 K77 E78 E80 D81 N85 G87 R88 T91 F95 K147 F148 E48 L53 Y56 D59 F60 I71 V75 K78 E79 E81 D82 N86 G88 R89 T92 F96 K148 F149
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:2vof, PDBe:2vof, PDBj:2vof
PDBsum2vof
PubMed18462686
UniProtQ07440|B2LA1_MOUSE Bcl-2-related protein A1 (Gene Name=Bcl2a1)

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