Structure of PDB 2qs4 Chain C

Receptor sequence

>2qs4C (length=251) Species: 10116 (Rattus norvegicus) [Search protein sequence]

RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDV
KLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIST
YEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN
LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG
N

3D structure

PDB

2qs4 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists.

Chain

Resolution

1.58 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LY5	C	Y61 P88 T90 R95 V137 S141 T142 S173 M189 E190 Y216	Y58 P85 T87 R92 V134 S138 T139 S170 M186 E187 Y213	MOAD: Kd=38nM

Gene Ontology

	Molecular Function
GO:0015276	ligand-gated monoatomic ion channel activity

	Cellular Component
GO:0016020	membrane

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:2qs4, PDBe:2qs4, PDBj:2qs4
PDBsum	2qs4
PubMed	20558186
UniProt	P22756\|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

[Back to BioLiP]

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417