BioLiP

Structure of PDB 2oic Chain C

Receptor sequence

>2oicC (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]

SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTV
AVKKLEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNG
SLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANIL
LDEAFTAKISDFGTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLL
EIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEA
MYSVASQCLHEKKNKRPDIKKVQQLLQEMT

3D structure

PDB

2oic Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.

Chain

Resolution

2.4 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1)	D143 K145 A147 N148 D161 T173
Enzyme Commision number	2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	STU	C	M192 G195 A211 Y262 Y264 M265 G268 A315 N316 L318	M32 G35 A51 Y94 Y96 M97 G100 A147 N148 L150	MOAD: ic50=4nM

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation
GO:0007165	signal transduction

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Molecular Function

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Biological Process

PDB	RCSB:2oic, PDBe:2oic, PDBj:2oic
PDBsum	2oic
PubMed	17312103
UniProt	Q9NWZ3\|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)