BioLiP

Structure of PDB 2ggx Chain C

Receptor sequence

>2ggxC (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]

ASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPF
TEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKF
TYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCE
F

3D structure

PDB

2ggx Contributions of Phenylalanine 335 to Ligand Recognition by Human Surfactant Protein D: ring interactions with Sp-D ligands

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	C	E321 N323 E329 N341 D342	E117 N119 E125 N137 D138
BS02	CA	C	D297 E301 D324 E329 D330	D93 E97 D120 E125 D126
BS03	CA	C	E301 D330	E97 D126
BS04	NPJ	C	E321 N323 E329 F335 T336 N337 N341 R343	E117 N119 E125 F131 T132 N133 N137 R139	MOAD: ic50=0.32mM

External links

PDB	RCSB:2ggx, PDBe:2ggx, PDBj:2ggx
PDBsum	2ggx
PubMed	16636058
UniProt	P35247\|SFTPD_HUMAN Pulmonary surfactant-associated protein D (Gene Name=SFTPD)

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