BioLiP

Structure of PDB 1o5o Chain C

Receptor sequence

>1o5oC (length=210) Species: 2336 (Thermotoga maritima) [Search protein sequence]

HMKNLVVVDHPLIKHKLTIMRDKNTGPKEFRELLREITLLLAYEATRHLK
CEEVEVETPITKTIGYRINDKDIVVVPILRAGLVMADGILELLPNASVGH
IGIYRDPETLQAVEYYAKLPPLNDDKEVFLLDPMLATGVSSIKAIEILKE
NGAKKITLVALIAAPEGVEAVEKKYEDVKIYVAALDERLNDHGYIIPGLG
DAGDRLFRTK

3D structure

PDB

1o5o Crystal structure of Uracil phosphoribosyltransferase (TM0721) from Thermotoga maritima at 2.30 A resolution

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	R104 T108 D200 D203
Catalytic site (residue number reindexed from 1)	R105 T109 D201 D204
Enzyme Commision number	2.4.2.9: uracil phosphoribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	U5P	C	R104 M133 A135 T136 G137 S139 Y193 I194 G199	R105 M134 A136 T137 G138 S140 Y194 I195 G200

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0004845	uracil phosphoribosyltransferase activity
GO:0005525	GTP binding
GO:0016757	glycosyltransferase activity

	Biological Process
GO:0006223	uracil salvage
GO:0008655	pyrimidine-containing compound salvage
GO:0044206	UMP salvage

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:1o5o, PDBe:1o5o, PDBj:1o5o
PDBsum	1o5o
PubMed
UniProt	Q9WZI0\|UPP_THEMA Uracil phosphoribosyltransferase (Gene Name=upp)