Structure of PDB 1nb5 Chain C

Receptor sequence

>1nb5C (length=220) Species: 9823 (Sus scrofa) [Search protein sequence]

YPPSMDWRKKGNFVSPVKNQGSCGSCWTFSTTGALESAVAIATGKMLSLA
EQQLVDCAQNFNNHGCQGGLPSQAFEYIRYNKGIMGEDTYPYKGQDDHCK
FQPDKAIAFVKDVANITMNDEEAMVEAVALYNPVSFAFEVTNDFLMYRKG
IYSSTSCHKTPDKVNHAVLAVGYGEENGIPYWIVKNSWGPQWGMNGYFLI
ERGKNMCGLAACASYPIPLV

3D structure

PDB

1nb5 Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases

Chain

Resolution

2.4 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Q19 C25 T31 H159
Catalytic site (residue number reindexed from 1)	Q20 C26 T32 H166
Enzyme Commision number	3.4.22.16: cathepsin H.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	N59 H61 S69 Q70 N112 V157 C205 S207	N62 H64 S72 Q73 N115 V164 C212 S214

Gene Ontology

	Molecular Function
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:1nb5, PDBe:1nb5, PDBj:1nb5
PDBsum	1nb5
PubMed	12581647
UniProt	O46427\|CATH_PIG Pro-cathepsin H (Gene Name=CTSH)

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