Structure of PDB 1ffi Chain C

Receptor sequence

>1ffiC (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PQITLWKRPLVTIKIGGQLKEALLDTGADNTVIEEMSLPGRWKPKMIGGI
GGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF

3D structure

PDB

1ffi Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.

Chain

Resolution

1.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2NC	C	D25 G27 A28 D29 N30 G48 G49 I84	D25 G27 A28 D29 N30 G48 G49 I84

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:1ffi, PDBe:1ffi, PDBj:1ffi
PDBsum	1ffi
PubMed	11340661
UniProt	P04587\|POL_HV1B5 Gag-Pol polyprotein (Gene Name=gag-pol)

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