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BioLiP

Structure of PDB 8po8 Chain B

Receptor sequence
>8po8B (length=615) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LTFTALQQRLDSLMLRDRLRFSRRLHGVKKVKNPDAQQAIFQEMAKEIDQ
AAGKVLLREAARPEITYPDNLPVSQKKQDILEAIRDHQVVIVAGETGSGK
TTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGY
KVRFSNHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNI
DFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPV
EVRYRPITERDQLQAIFDAVDELSQESPGDILIFMSGEREIRDTADALNK
LNLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKY
VIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLY
SEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNI
QDGVRLLEELGAITTDSAYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCV
REAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNYL
GEQQKALSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSE
PAEYREIHIALLTGL
3D structure
PDB8po8 Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
ChainB
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R22 D23 R26 R16 D17 R20
BS02 dna B L25 R26 R29 R30 G33 V34 M50 Q184 L19 R20 R23 R24 G27 V28 M44 Q178
BS03 ADP B T102 G103 S104 G105 K106 T107 T108 R141 F336 T356 T96 G97 S98 G99 K100 T101 T102 R135 F324 T344
BS04 MG B T107 E198 T101 E192
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:8po8, PDBe:8po8, PDBj:8po8
PDBsum8po8
PubMed38412313
UniProtP43329|HRPA_ECOLI ATP-dependent RNA helicase HrpA (Gene Name=hrpA)

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