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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 8h10 Chain B

Receptor sequence >8h10B (length=1026) Species: 2901879 (Severe acute respiratory syndrome coronavirus) [Search protein sequence] TQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHNPVIPFKDGI YFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPF FMIFDNAFNCTFEYISDKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSG FNTLKPIFKLPLGINITNFRAILTAAAAYFVGYLKPTTFMLKYDENGTIT DAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLC PFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVCATK LNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAW NTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALN CYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQ CVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDI SPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYS TGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTQKSIVAYTMSL GADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTEC ANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGG FNFSQILPDPLKPTKRSFIEDLLFNKVTLADLICAQKFNGLTVLPPLLTD DMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLY ENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLS SNFGAISSVLNDILSRLCKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAE IRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTY VPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITT DNTFVSGNCDVVIGIINNTVYDPLQP

3D structure PDB 8h10 Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Chain B Resolution 2.99 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number ?

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 EIC B I345 A350 Y352 Y356 F361 F364 I272 A277 Y279 Y283 F288 F291 BS02 BLA B V98 R99 I116 I117 N118 R183 F185 K198 V61 R62 I79 I80 N81 R121 F123 K136

Gene Ontology Molecular Function GO:0005515 protein binding GO:0042802 identical protein binding GO:0046789 host cell surface receptor binding

	Biological Process
GO:0019062	virion attachment to host cell
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0039587	suppression by virus of host tetherin activity
GO:0039654	fusion of virus membrane with host endosome membrane
GO:0046598	positive regulation of viral entry into host cell
GO:0046718	symbiont entry into host cell
GO:0046813	receptor-mediated virion attachment to host cell
GO:0052170	symbiont-mediated suppression of host innate immune response
GO:0061025	membrane fusion
GO:0075509	endocytosis involved in viral entry into host cell

	Cellular Component
GO:0016020	membrane
GO:0019031	viral envelope
GO:0020002	host cell plasma membrane
GO:0044173	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036	virion membrane

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