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Structure of PDB 6qra Chain B

Receptor sequence >6qraB (length=206) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence] SMKIDVVTIFPEYLQPVGLVDVAVHDLRRWTHDVHKSVDDSPYGGGPGMV MKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWSTEDHLVIACGR YEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIEAVLRLVPGVA SLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQSRQRTIERRPDL LGFDSP

3D structure PDB 6qra Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches. Chain B Resolution 1.71 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) P85 E112 R154 Catalytic site (residue number reindexed from 1) P75 E102 R144 Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 JDK B P83 T84 P85 G109 R110 Y111 E112 S132 I133 G134 Y136 L138 N139 G140 G141 P73 T74 P75 G99 R100 Y101 E102 S122 I123 G124 Y126 L128 N129 G130 G131 MOAD: Kd=710nM PDBbind-CN: -logKd/Ki=6.15,Kd=710nM

Gene Ontology Molecular Function GO:0008168 methyltransferase activity GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity

	Biological Process
GO:0002939	tRNA N1-guanine methylation
GO:0006400	tRNA modification
GO:0008033	tRNA processing
GO:0032259	methylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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