Structure of PDB 5nvc Chain B

Receptor sequence

>5nvcB (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]

GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFSAM

3D structure

PDB

5nvc 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.

Chain

Resolution

1.6 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	C1081 H1084 C1089 C1092	C130 H133 C138 C141
BS02	9AN	B	H1031 G1032 S1033 H1048 Y1050 Y1060 K1067 S1068 Y1071	H80 G81 S82 H97 Y99 Y109 K116 S117 Y120	MOAD: ic50=650nM

Gene Ontology

	Molecular Function
GO:0003950	NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:5nvc, PDBe:5nvc, PDBj:5nvc
PDBsum	5nvc
PubMed	29374194
UniProt	Q9H2K2\|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

[Back to BioLiP]

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417