Structure of PDB 4z8m Chain B

Receptor sequence

>4z8mB (length=158) Species: 9606 (Homo sapiens) [Search protein sequence]

NGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPT
AQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEI
MDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEV
STRFDLEH

3D structure

PDB

4z8m Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling

Chain

Resolution

2.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	E455 L457	E106 L108
BS02	peptide	B	R392 F410 L457 P468 G470 F471 G472 Y473	R43 F61 L108 P119 G121 F122 G123 Y124

Gene Ontology

	Molecular Function
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding

	Biological Process
GO:0016567	protein ubiquitination
GO:0043122	regulation of canonical NF-kappaB signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:4z8m, PDBe:4z8m, PDBj:4z8m
PDBsum	4z8m
PubMed	26385923
UniProt	Q9Y4K3\|TRAF6_HUMAN TNF receptor-associated factor 6 (Gene Name=TRAF6)

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