Structure of PDB 3kjd Chain B

Receptor sequence

>3kjdB (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]

DLGTENLYFQSMDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTV
AQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIR
TQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPL
DHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHN
RMLLWHGSRMSNWVGILSHGLRIAHPEAPITGYMFGKGIYFADMSSKSAN
YCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMA
PSSAHFVTLNGSTVPLGPASDTGIYTLNYNEYIVYNPNQVRMRYLLKVQF
NF

3D structure

PDB

3kjd Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

Chain

Resolution

1.95 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	K264 A265 I289 F305 T307 S470 Y473 E558
Catalytic site (residue number reindexed from 1)	K42 A43 I67 F83 T85 S248 Y251 E331
Enzyme Commision number	2.4.2.- 2.4.2.30: NAD(+) ADP-ribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	78P	B	H428 G429 Y462 F463 S470 Y473	H206 G207 Y240 F241 S248 Y251	MOAD: Kd=2.9nM BindingDB: IC50=1.3nM,Kd=5.8nM

Gene Ontology

	Molecular Function
GO:0003950	NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:3kjd, PDBe:3kjd, PDBj:3kjd
PDBsum	3kjd
PubMed	20092359
UniProt	Q9UGN5\|PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (Gene Name=PARP2)

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