Structure of PDB 3eov Chain B

Receptor sequence

>3eovB (length=166) Species: 5661 (Leishmania donovani) [Search protein sequence]

EPEVTAKVYFDVMIDSEPLGRITIGLFGKDAPLTTENFRQLCTGEHGFGY
KDSIFHRVIQNFMIQGGDFTNFDGTGGKSIYGEKFADENLNVKHFVGALS
MANAGPNTNGSQFFITTAPTPWLDGRHVVFGKVLDGMDVVLRIEKTKTNS
HDRPVKPVKIVASGEL

3D structure

PDB

3eov Structure of Cyclophilin from Leishmania Donovani Bound to Cyclosporin at 2.6 A Resolution: Correlation between Structure and Thermodynamic Data.

Chain

Resolution

2.6 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	R78 F83 Q86 N124 F135 L144 H148
Catalytic site (residue number reindexed from 1)	R57 F62 Q65 N103 F114 L123 H127
Enzyme Commision number	5.2.1.8: peptidylprolyl isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	R78 F83 Q86 G95 A123 N124 Q133 F135 W143 H148	R57 F62 Q65 G74 A102 N103 Q112 F114 W122 H127

Gene Ontology

	Molecular Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity

	Biological Process
GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding

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Molecular Function

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Biological Process

External links

PDB	RCSB:3eov, PDBe:3eov, PDBj:3eov
PDBsum	3eov
PubMed	19923714
UniProt	Q9U9R3

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