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Structure of PDB 3cv6 Chain B

Receptor sequence >3cv6B (length=323) Species: 10090 (Mus musculus) [Search protein sequence] MNSKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFD SASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLE RSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEA MEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQM KLLDFCKSKDIVLVAYGVLGTQRYPPWVDQNSPVLLDEPVLGSMAKKYNR TPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN RNMRYIPAAIFKGHPNWPFLDEY

3D structure PDB 3cv6 Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate. Chain B Resolution 2.1 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) D50 Y55 K84 H117 Catalytic site (residue number reindexed from 1) D50 Y55 K84 H117 Enzyme Commision number 1.1.1.- 1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 NAP B G22 A24 D50 Y55 Q190 Y216 G217 L219 T221 Q222 Y224 A253 T270 S271 K273 R276 E279 N280 G22 A24 D50 Y55 Q190 Y216 G217 L219 T221 Q222 Y224 A253 T270 S271 K273 R276 E279 N280 BS02 HXS B A24 L25 Y55 H117 Y118 Y224 W227 A24 L25 Y55 H117 Y118 Y224 W227 MOAD: ic50=50uM

Gene Ontology Molecular Function GO:0004033 aldo-keto reductase (NADPH) activity GO:0005496 steroid binding GO:0016491 oxidoreductase activity GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0047023 androsterone dehydrogenase activity GO:0047024 5alpha-androstane-3beta,17beta-diol dehydrogenase activity GO:0070401 NADP+ binding GO:0070402 NADPH binding GO:0072555 17-beta-ketosteroid reductase (NADPH) activity GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:1902121 lithocholic acid binding

	Biological Process
GO:0006694	steroid biosynthetic process
GO:0008202	steroid metabolic process

	Cellular Component
GO:0005737	cytoplasm

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