Structure of PDB 2pw3 Chain B

Receptor sequence

>2pw3B (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]

QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKI
PVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTD
LEILAAIFASAIHNVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVG
FKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV
ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIM
EEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL
VHPDAQDILDTLEDNREWYQSTIPQ

3D structure

PDB

2pw3 The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.

Chain

Resolution

1.56 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H164 H200 N201 D318	H77 H113 N114 D231	Manual survey: Km=56nM (17562314)
BS02	CMP	B	H160 M273 L319 I336 Q369 F372	H73 M186 L232 I249 Q282 F285	Manual survey: Km=56nM (17562314)

Gene Ontology

	Molecular Function
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081	phosphoric diester hydrolase activity

	Biological Process
GO:0007165	signal transduction

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2pw3, PDBe:2pw3, PDBj:2pw3
PDBsum	2pw3
PubMed	17582435
UniProt	Q08499\|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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