Structure of PDB 2bw7 Chain B

Receptor sequence

>2bw7B (length=193) Species: 118562 (Arthrospira platensis) [Search protein sequence]

MRPEPRLITILFSDIVGFTRMSNALQSQGVAELLNEYLGEMTRAVFENQG
TVDKFVGDAIMALYGAPEEMSPSEQVRRAIATARQMLVALEKLNQGWQER
GLVGRPPVRFRCGIHQGMAVVGLFGSQERSDFTAIGPSVNIAARLQEATA
PNSIMVSAMVAQYVPDEEIIKREFLELKGIDEPVMTCVINPNM

3D structure

PDB

2bw7 A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.13.3: histidine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	APC	B	A1140 I1141 G1142 P1143 V1145 N1146	A134 I135 G136 P137 V139 N140
BS02	APC	B	D1017 I1018 V1019 G1020 F1021 T1022 G1060 R1117	D14 I15 V16 G17 F18 T19 G57 R111
BS03	CA	B	D1017 I1018 D1061	D14 I15 D58
BS04	ECS	B	F1015 D1017 A1062 N1146 A1149 R1150 E1153	F12 D14 A59 N140 A143 R144 E147	MOAD: ic50~2uM PDBbind-CN: -logKd/Ki=5.70,IC50=2uM

Gene Ontology

	Biological Process
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

View graph for
Biological Process

External links

PDB	RCSB:2bw7, PDBe:2bw7, PDBj:2bw7
PDBsum	2bw7
PubMed	16002394
UniProt	O32393

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