Structure of PDB 1wc3 Chain B

Receptor sequence

>1wc3B (length=194) Species: 118562 (Arthrospira platensis) [Search protein sequence]

MRPEPRLITILFSDIVGFTRMSNALQSQGVAELLNEYLGEMTRAVFENQG
TVDKFVGDAIMALYGAPEEMSPSEQVRRAIATARQMLVALEKLNQGWQER
GLVGRVPPVRFRCGIHQGMAVVGLFGSQERSDFTAIGPSVNIAARLQEAT
APNSIMVSAMVAQYVPDEEIIKREFLELKGIDEPVMTCVINPNM

3D structure

PDB

1wc3 Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.13.3: histidine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	APC	B	F1015 K1057 M1064 V1145 N1146 A1149 R1150 K1184 M1199	F12 K54 M61 V140 N141 A144 R145 K179 M194	MOAD: Ki=0.3mM
BS02	APC	B	G1020 F1021 T1022 V1059 G1060 D1061	G17 F18 T19 V56 G57 D58	MOAD: Ki=0.3mM

Gene Ontology

	Biological Process
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

View graph for
Biological Process

External links

PDB	RCSB:1wc3, PDBe:1wc3, PDBj:1wc3
PDBsum	1wc3
PubMed	15619637
UniProt	O32393

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